1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. P391 Collect spillage.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, upper respiratory system Target Organs: Eyes, skin, respiratory system, thyroid (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Skin decontamination: Skin contamination should he treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be, obtained without delay. /Herbicides/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Bromacil may be ignited by heat or open flame. ... Use dry chemical, carbon dioxide, water spray, or foam extinguishers. ... From a secure, explosion-proof location, use water spray to coll exposed containers. ...

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

6.3 Methods and materials for containment and cleaning up

Remove all ignition sources. Absorb liquid containing Bromacil in vermiculite, dry sand, earth, or similar material. Collect powdered material in the most convenient and safe manner adn deposit in sealed containers. Ventilate area of spill or leak after clean-up is complete. ...

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Keep in a well-ventilated room. Separated from strong oxidants and strong acids.Do not contaminate water, other pesticides, fertilizer, food or feed in storage. Store in original container. Keep tightly closed in a dry, cool and wellventilated place. Keep out of the reach of children. /DuPont Hyvar X Herbicide/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 1 ppm (10 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable to 0 deg F, but water-soluble formulations become less soluble with exposed to air.

10.3 Possibility of hazardous reactions

Active ingredient and dry formulations are non-flammable; the liquid formulation (HYVAR-XL) is a combustible mixture which should be kept away from heat and open flame.BROMACIL is incompatible with the following: Strong acids (decomposes slowly), oxidizers, heat, sparks, open flames (NIOSH, 2016).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong acids (decomposes slowly), oxidizers, heat, sparks, open flames.

10.6 Hazardous decomposition products

... Decomposes slowly in strong acids.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat male oral 5200 mg/kg
• Inhalation: LC50 Rat inhalation >4.8 mg/L air/4 hr
• Dermal: LD50 Rabbit percutaneous >5000 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group C Possible Human Carcinogen

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill sunfish); Concentration: 71 ppm for 48 hr /Conditions of bioassay not specified in source examined
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: 121000 ug/L for 48 hr (95% confidence interval: 111000-148000 ug/L); Effect: intoxication, immobilization /96.6% purity
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static; Concentration: 6.8 ug/L for 5 days (95% confidence interval: 5.9-7.8 ug/L); Effect: population abundance /96.5% purity
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The microbial degradation of bromacil in aerobic soil is slow with a half-life of 275 days in silty clay loam soil incubated for up to 12 months. Carbon dioxide was the major degradate with 5-bromo-6-methyluracil, 5-bromo-3-(alpha-hydroxymethylpropyl)-6-methyluracil, 5-bromo-3-sec-butyl-6-hydroxymethyluracil, 5-bromo-3-(2-hydroxy-1-methylpropyl)-6-methyluracil and 3-sec-butyl-6-methyluracil found as minor metabolites(1). Bromacil was degraded within 4 to 6 months when single applications were made to soil; however, when two applications were used, bromacil persisted in the top 75 mm of soil for nearly a year(2). The mineralization half-life of (14)C-labeled bromacil, incubated in loamy sand and mucky peat soils, was estimated to range from 5,429 to 46,200 days(3). Bromacil estimated half-life is 12-46 days in two New Zealand soils; Motupiko silt loam (pH 5.7, 24% sand, 57% silt, 19% clay, 2.4% organic content) Waikiwi silt loam (pH 5.5, 7% sand, 69% silt, 24% clay, 3.9% organic content)(4).

12.3 Bioaccumulative potential

The bioconcentration of bromacil in bluegill sunfish (Lepomis macrochirus) was studied over a 28-day period using flow-through conditions(1). Bluegill sunfish exposed to 10.6 ppm bromacil had BCF values for muscle, viscera, carcass, and whole fish of 49, 72, 22, and 26.5, respectively(1). At 1.0 ppm, maximum BCF values were 4.6, 8.3, 2.2, and 2.8 for muscle, viscera, carcass, and whole fish, respectively(1). Depuration was rapid, with >96% of the accumulated residues eliminated from the fish tissues by day 3 of the depuration period. A BCF of 3.2 was measured in fathead minnow(2). A log BCF of 0.35242 in bluegill sunfish exposed for 28 days has also been reported(3), corresponding to a BCF of 2.20(SRC). According to a classification scheme(4), these BCF values suggest that bioconcentration in aquatic organisms is low. [

12.4 Mobility in soil

Bromacil is very mobile in sand, sandy loam, clay loam and silt loam soils; aged bromacil residues are very mobile in silt loam soils(1). Extensive data exists as evidence that bromacil leaches to ground water as a result of normal agricultural use(1). An average Koc value of 23 was determined from experimental values determined in 8 soils and 4 sediments(2). Koc values of 25 to 50 for for Israeli soils(3), 55 to 126(4), 46 to 93 for 7 sandy Florida soils(5), and 76 to 129 for a mucky peat and a loamy sand Oregon soils incubated at temperatures of 4 and 25°C(6) have been reported. Koc values in sand (FL), sandy loam (CA), clay loam (MD), and silt loam (DE) were 12, 33, 2.3, and 14, respectively(7). According to a classification scheme(8), these Koc values suggest that bromacil is expected to have very high to moderate mobility in soil. In soil column leaching studies, bromacil readily leached from loess and sandy soils, but was retained in organic-rich soils(6). As the pH increased from 3 to 12, less adsorption of bromacil to Ca-montmorillonite was measured(4). In 7 sandy soils, a rainfall of 20-23 cm displaced over 96% of applied bromacil(5). Koc values were slightly higher at lower temperatures(6). Maximum bromacil concentrations of 1.25 ppm were detected in groundwater (depths of 4.5-6 meters) three months after the herbicide was applied to a surface of Lakeland, FL sandy soil bearing scrub vegetation of small oaks and poor grasses(9). The pKa of bromacil is 9.30(10), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(11). Desorption of bromacil from Cuban soils were reported as 51.98 and 67.00% from a red ferralitic soil and a brown plastic soil, respectively; the specific adsorption constants are 2.89 and 23.9 ug/g, respectively(12). Adsorption coefficients 1.79 and 4.59 for Motupiko topsoil (1-10 cm) and subsoil (40-50 cm), respectively, and 1.57 for Waikiwi topsoil (1-10 cm) have been reported for two Wakefield, Nelson, New Zealand soils. Soil characteristics are as follows: Motupiko silt loam (pH 5.7, 24% sand, 57% silt, 19% clay, 2.4% organic content) Waikiwi silt loam (pH 5.5, 7% sand, 69% silt, 24% clay, 3.9% organic content)(13).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.